Toxicology Excellence for Risk Assessment (TERA)

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Phone: 513-542-7475
Fax: 513-542-7487

Email: TERA@TERA.org

Scientific Rationale for Approaches to Derive Database and Toxicodynamic Uncertainty Factors to Protect Children’s Health


What:     Peer Consultation on the Scientific Rationale for Approaches to Derive Database and Toxicodynamic Uncertainty Factors to Protect Children’s Health 
When:   September 19, 2005, 8:30am - 5:00pm
Where:   Northern Kentucky University Metropolitan Education and Training Services (METS), Erlanger, Kentucky

The goal of the peer consultation was to obtain expert input on the scientific rationale for selection of uncertainty factors to address issues associated with developmental, neonatal, child, or reproductive toxicity studies when deriving reference doses (RfDs). 

Two distinct data compilations were discussed.  The first compilation related to the current procedure for deriving human RfDs when no adequate human or animal reproductive or developmental studies are available.  The panel discussed the database uncertainty factor, developed by EPA in the late 1980s and based largely on pesticide studies, in light of additional human and experimental animal toxicity data for diverse classes of chemicals and exposure routes.  The second compilation related to the scientific rationale for making animal-to-human extrapolations of developmental, neonatal, or reproductive endpoints that are reported as critical effects in experimental animal studies.  The panel explored approaches for applying chemical specific adjustment factors (CSAFs) for toxicodynamics based on known similarities and differences in physiology and anatomy.  Both of these compilations have usefulness for uncertainty factor selection when deriving RfDs.

TERA Contact: Dr. Dan Briggs: phone 231-276-0126; email briggs@tera.org Alternate Contact:  Ms. Jacqueline Patterson: 513-521-7426;email patterson@tera.org

 

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