TERA Methods Development

 The field of risk assessment is changing rapidly as the "omics" revolution and the burgeoning field of molecular toxicology provide a wealth of data that were not traditionally available. TERA's research seeks to enhance the use of data on mode and mechanism of action to inform qualitative and quantitative aspects of risk assessment. We do this by designing targeted studies and decision frameworks to address key MOA questions, incorporating biomarker data to extend the dose-response curve using advanced PBPK and BBDR modeling approaches, and developing approaches to evaluate health risk assessment for potentially-susceptible populations and other areas of uncertainty in risk assessment.


Wheat 246

 

Expertise:

Emerging Risk Issues

 

TERA stays at the cutting edge of developing issues.  For example, current work projects address novel techniques related to modeling chemical mixtures, assessment issues for human variability in sensitivity, and methods to address complex temporal exposure patterns...Learn More

Grass

 

Expertise:

    Mode of Action (MOA) Analysis and Dose-Response Frameworks

     

    Evaluation of mode of action (MOA) plays a critical role in both hazard characterization and dose-response portions of assessments.  TERA can work with interested parties to design and conduct studies targeted to address key MOA questions.  We have active research projects aimed at developing approaches to quantitatively describe the dose-response relationship for chemicals with multiple MOAs. One area of emphasis has centered on the use of early effects and systems biology to support dose-response assessment ...Learn More

Wheat 246

 

Expertise:

Quantitative Risk Assessment

 

Quantitative risk analysis provides data based risk estimates derived using mathematical modeling and
statistical analysis of experimental toxicity data. TERA scientists have extensive experience with the tools of
quantitative risk analysis, and continue to research and develop new analytical methods to improve risk
assessment...Learn More

 

Expertise: