Children's Risk

TERA has developed two documents addressing broad issues related to children’s risk, which will be discussed at upcoming peer consultation meetings.  One document presents a draft framework for evaluating the adequacy of the default uncertainty factor of 3.2 for human kinetic variability for protecting children, and the second one addresses uncertainty factor selection when deriving safe dose estimates to address reproductive or developmental toxicity concerns.  TERA has published on age-related differences in toxicokinetics and chemical sensitivity, and how these issues are taken into account in the current risk assessment paradigm (Dourson et al., 2002; Scheuplein et al., 2002).  To help address the key issue of how tissue dose to children and adults compares for a given environmental exposure, TERA has collected physiological parameters for neonatal animals for use in PBPK modeling (Gentry et al., 2005).  These data can be used to develop age-specific models to improve estimation of risk to children. 

TERA is also organizing peer consultations for the Voluntary Children’s Chemical Evaluation Program (VCCEP)This work provides ongoing contact with a broad range of leading scientists and their perspectives on addressing children’s risk from the hazard identification, dose-response and exposure perspectives.


Last updated:  02/01/2010