Toxicology Excellence for Risk Assessment (TERA)

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Phone: 513-542-7475
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Independent Peer Review for Acrylonitrile

A scientific peer review of a toxicological review and assessment for acrylonitrile was held on September 22-23, 2003 in Cincinnati Ohio. The meeting was held at the University of Cincinnati and was open to the public.  An independent Peer Review Panel reviewed an assessment that included derivation of oral and inhalation risk values, utilizing the best available science and current risk assessment methods and guidelines.  The Sapphire Group, Inc. on behalf of the Acrylonitrile Group prepared the assessment document. This independent peer review meeting was held under the International Toxicity Estimates for Risk (ITER) program of Toxicology Excellence for Risk Assessment (TERA).


Acrylonitrile is a building block chemical used to make numerous products, including acrylic fiber for clothing, blankets, carpeting and other fabrics; rugged plastics for computer and TV housings; and nitrile rubber for oil-resistant hoses.  Acrylonitrile is also identified as a Hazardous Air Pollutant and as such the U.S. Environmental Protection Agency (EPA) must consider the need to adopt various Clean Air Act regulations to reduce emissions. The assessment presented builds on EPA’s 1983 risk assessment which is currently reflected in the Agency’s Integrated Risk Information System (IRIS), but also incorporates the significant new information and methodologies that have been generated since that time.  The objective of this peer review was to review the updated scientific assessment of acrylonitrile and the risk values presented.

Post-Meeting Information and Documentation

The Sapphire Group Inc. and the Acrylonitrile Group revised their assessment document in response to the peer review.  A summary of the risk values and assessment for acrylonitrile are available on the International Toxicity Estimates for Risk database.

Link to ITER


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