Toxicology Excellence for Risk Assessment (TERA)

2300 Montana Avenue, Suite 409, Cincinnati OH 45211
Phone: 513-542-7475
Fax: 513-542-7487

Email:
TERA@TERA.org

Evaluating Adult-to-Child Toxicokinetic Differences Peer Consultation

 


Peer Consultation on the Draft Framework to Evaluate Adult-Child Differences in Inhalation Dosimetry of Gases: Application to Selected Systemically-Acting Volatile Organic Chemicals

 

Toxicology Excellence for Risk Assessment (TERA) conducted a peer consultation on the revised framework for evaluating the magnitude of adult-to-child toxicokinetic differences in inhalation dosimetry of gases.  A panel of expert scientists discussed and evaluateed the revised draft framework and provideed direction for finalizing it.  The original framework and meeting report can be found below (2005 Peer Consultation). 

In 2005, the same panel of experts met and held a peer consultation on the original draft framework.  The authors revised the original draft framework based on the feedback received during the 2005 peer consultation.  The original and revised frameworks and background materials were prepared by scientists from Toxicology Excellence for Risk Assessment (TERA) with assistance from several leading researchers in toxicokinetics and physiologically-based pharmacokinetic (PBPK) modeling.  The outcome of this peer consultation will be used to further refine the process of children’s risk assessment.  Funding for the peer consultation is from a cooperative agreement between the U.S. EPA and TERA

The peer consultation was held via a web meeting, using a conference call for the audio and a web meeting program for the presentation slides.  The meeting was open to the public.   

General Meeting Information

Meeting Documentation

2005 Peer Consultation on Initial Draft Framework

A panel of expert scientists conducted a Peer Consultation to evaluate a preliminary framework for evaluating whether the default uncertainty factor for human kinetic variability is adequate for protecting children.  The panel also provided direction for next steps to refine and expand the framework.  Note that the framework the panel discussed was not a finished product.  It was preliminary proposal presented to obtain opinions and guidance from leading experts on how it may be further developed for use in children's risk assessment.  The framework and background materials were prepared by scientists from Toxicology Excellence for Risk Assessment (TERA) and include ideas from several leading researchers in toxicokinetics and physiologically-based pharmacokinetic (PBPK) modeling.

For additional information, contact Ms. Patricia Nance at 513-542-7475, ext. 25, or Ms. Jacqueline Patterson at 513-521-7426.

 

                                 © 2009 Toxicology Excellence for Risk Assessment