Peer Consultation on the Draft Framework
to Evaluate Adult-Child Differences in
Inhalation Dosimetry of Gases: Application to Selected
Systemically-Acting Volatile Organic Chemicals
Toxicology Excellence for Risk Assessment (TERA)
conducted a peer consultation on the revised framework for evaluating
the magnitude of adult-to-child toxicokinetic differences in inhalation dosimetry of gases. A panel of expert scientists discussed and
evaluateed the revised draft framework and provideed direction for
finalizing it. The original framework and meeting report can be found
below (2005 Peer Consultation).
In 2005, the same panel of experts met and held a
peer consultation on the original draft framework. The authors revised the
original draft framework based on the feedback received during the 2005
peer consultation. The original and revised frameworks and background
materials were prepared by scientists from Toxicology Excellence for
Risk Assessment (TERA) with assistance from several leading
researchers in toxicokinetics and physiologically-based pharmacokinetic
(PBPK) modeling. The outcome of this peer consultation will be used to
further refine the process of children’s risk assessment. Funding for
the peer consultation is from a cooperative agreement between the U.S.
EPA and TERA.
The peer consultation was held via a web meeting, using
a conference call for the audio and a web meeting program for the
presentation slides. The meeting was open to the public.
General Meeting Information
2005 Peer Consultation on Initial Draft Framework
A panel of expert scientists conducted a
Peer Consultation to evaluate a preliminary framework for evaluating
whether the default uncertainty factor for human kinetic variability is
adequate for protecting children. The panel also provided direction for
next steps to refine and expand the framework. Note that the framework
the panel discussed was not a finished product. It was preliminary
proposal presented to obtain opinions and guidance from leading experts
on how it may be further developed for use in children's risk
assessment. The framework and background materials were prepared by
scientists from Toxicology Excellence for Risk Assessment (TERA)
and include ideas from several leading researchers in toxicokinetics and
physiologically-based pharmacokinetic (PBPK) modeling.
For additional information, contact Ms. Patricia
Nance at 513-542-7475, ext. 25, or Ms. Jacqueline Patterson at