Lessons Learned, Challenges, and Opportunities: The US Endocrine Disruptor Screening Program

Date: April 23-24, 2013

Location: North Carolina Biotechnology Center, Research Triangle Park, North Carolina


Workshop Presentations



Welcome and Introductions


8:15 - 8:45      Welcome and Workshop Overview - Dr. Daland Juberg, Workshop Chair
“Why are we here?” - EDSP Workshop Organizing Committee


Session I - Performance of the EDSP Tier I Screening Assays; Insights from
Conducting Assays for List 1 Chemicals


8:45 - 8:50      Introduction to Session I - Dr. Susan Borghoff, Session Chair


8:50 - 9:30      Review of in vitro Assays - Validation Results and Methods for Improving in vitro Tier 1 Endocrine Disruption Screening Assays - – Dr. Colleen Toole, Ceetox Presentation


9:30 - 10:10    Review of in vivo Mammalian Assays - Challenges and Considerations for Conducting and Interpreting These Screening Assays - Dr. Leah Zorrilla, ILS, Inc.



10:10- 10:45   BREAK     


10:45 - 11:30  Review of Non-mammalian Assays - Challenges and Potential Solutions for the Conduct and Interpretation of the Amphibian Metamorphosis Assay and the Fish Short Term Reproduction Assay - – Dr. Katherine Coady, The Dow Chemical Company




11:30 - 12:15  Panel Discussion and Audience Q&A : Dr. Ronald Biever, Smithers Viscient; Dr. Donald Stump, WIL Research; Dr. Kun (Sue) Yi, Syngenta Crop Protection



12:15 - 1:15    LUNCH


Session II - Practical Applications of Tier 1 Data


1:15 - 1:20      Introduction to Session II - Dr. Sue Marty, Session Chair


1:20 - 2:00      A Two-Tiered-Testing Decision Tree for Assays in the USEPA-EDSP Screening Battery:   Using 15 years of experience to improve screening and testing for endocrine active chemicals - Dr. L. Earl Gray Jr., US Environmental Protection Agency



2:00 - 2:40      Pulling it Together – Preparing for a Weight of Evidence Assessment on Endocrine Activity – Dr. Sue Marty, The Dow Chemical Co.



2:40 - 3:15      BREAK


3:15 - 3:55      A Weight of Evidence Approach to Examine Endocrine Activity - Dr. Christopher Borgert, Applied Pharmacology & Toxicology, Inc.



3:55 - 4:45      Panel Discussion and Audience Q&A: Patricia Bishop, PETA; Dr. Kevin Crofton, US EPA; Dr. Ellen Mihaich, ER2 and Endocrine Policy Forum


4:45 - 5:00      Day One Wrap Up and Prelude to Day Two - Dr. Daland Juberg, Workshop Chair





Welcome Back and Poster Review


8:00 - 8:25      Welcome Back
Report from Poster Session, Dr. Richard Becker, American Chemistry Council




Session III- Considerations in the Future of Endocrine Testing

8:25 - 8:30      Introduction to Session III - Dr. Warren Casey, NIEHS; Dr. Jack Fowle, EPA, retired; and, Dr. Richard Becker, American Chemistry Council; Session Co-Chairs



8:30 - 9:00      EPA ToxCast HTS Assays and Prediction Models for Estrogen, Androgen, Thyroid and Steroidogenesis Pathways - Dr. David Dix, EPA NCCT




9:00 - 9:30      Tier 1 and Done: Developing in vitro Cell-based Assays of Endocrine Pathways Sufficient by Themselves for 21st Century Risk Assessment – Dr. Mel Andersen, The Hamner Institutes for Health Sciences



9:30 - 10:00    Mapping the Human Toxome by Systems Toxicology - Using ED as a Proof of Concept - Dr. Thomas Hartung, Center for Alternatives to Animal Testing, Johns Hopkins 


10:00- 10:15   BREAK


10:15 - 10:35  The Future of Endocrine Screening: An Animal Welfare Perspective – Dr. Catherine Willett, Humane Society of the United States



10:35 - 10:55  Road Map for Building Scientific Confidence in HTP Assays- Dr. David Geter, Bayer CropScience, Presented by Dr. Lisa Ortego



10:55 - 11:15  Designing the Next Generation of Sustainable Chemicals - Thaddeus Schug, NIEHS




11:15 - 12:00  Panel Discussion and Audience Q&A



12:00 - 12:45  LUNCH



Session IV - Participant Discussion


12:45 - 2:30    Dr. James C. Lamb, IV, Exponent, Inc., Opening Remarks
Dr. Michael Dourson, TERA, Facilitator



Closing Remarks


2:30 - 2:45      Dr. Daland Juberg, Workshop Chair






For more information, contact Jacqueline Patterson (patterson@tera.org or 513-542-7475)