HSN: 535

NAME: DICHLOROETHANE, 1,1-

CAS-RN: 75-34-3

DATE: 20180416

Risk Values - Summary Table

Summary Risk Table for:DICHLOROETHANE, 1,1-
Risk Value Parameter OrganizationATSDRHealth CanadaIARCIPCSIPRVITER PRNSF IntlRIVMTCEQU.S.EPA
Oral: Non-Cancer
green check
--
--
--
--
--
--
--
--
--
Oral: Cancer
green check
--
--
--
--
--
--
--
--
green check
Inhalation: Non-Cancer
green check
--
--
--
--
--
--
--
--
--
Inhalation: Cancer
green check
--
--
--
--
--
--
--
--
green check
green check = Chemical evaluated and ITER data online.


Noncancer Oral Risk Values Table:

ITER Noncancer Oral Risk Table for: DICHLOROETHANE, 1,1-
Risk Value Parameter OrganizationATSDRHealth CanadaIARCIPCSIPRVITER PRNSF IntlRIVMTCEQU.S.EPA
Risk Value Namechronic MRL
--
--
--
--
--
--
--
--
--
Risk Value*NA
--
--
--
--
--
--
--
--
--
Year2015
--
--
--
--
--
--
--
--
--
Base(Experimental)*NA
--
--
--
--
--
--
--
--
--
Basis(Adjusted)*NA
--
--
--
--
--
--
--
--
--
Uncertainty FactorNA
--
--
--
--
--
--
--
--
--
Critical Organ or EffectNA
--
--
--
--
--
--
--
--
--
SpeciesNA
--
--
--
--
--
--
--
--
--
StudyNA
--
--
--
--
--
--
--
--
--
Biomonitoring Blood
--
--
--
--
--
--
--
--
--
--
Biomonitoring Urine
--
--
--
--
--
--
--
--
--
--
View Specific:Click here
--
--
--
--
--
--
--
--
--
*In mg/kg body weight per day, unless otherwise specified.


Noncancer Oral Synopsis:

ATSDR has evaluated the noncancer oral toxicity data for 1,1-dichloroethane, but did not derive a chronic minimal risk level (MRL) because the oral studies have not identified a target of toxicity, thus precluding the derivation of oral MRLs.

Noncancer Oral Specifics:

ATSDR

PEER:
The ATSDR Toxicological Profile has undergone internal agency reviews and has been externally reviewed by a peer review panel.

MOREI:
ATSDR (Agency for Toxic Substances and Disease Registry). 2015. Toxicological Profile for 1,1-Dichloroethane. U.S. Department of Health and Human Services, Public Health Service. August. Available at http://www.atsdr.cdc.gov/ToxProfiles/tp.asp?id=718&;tid=129

For the list of ATSDR minimal risk levels (MRLs), see http://www.atsdr.cdc.gov/mrls/index.html


Cancer Oral Risk Values Table:

ITER Cancer Oral Risk Table for: DICHLOROETHANE, 1,1-
Risk Value Parameter OrganizationATSDRHealth CanadaIARCIPCSIPRVITER PRNSF IntlRIVMTCEQU.S.EPA
Risk Value NameNA
--
--
--
--
--
--
--
--
NA
Risk Value*NA
--
--
--
--
--
--
--
--
NA
Year2015
--
--
--
--
--
--
--
--
1990
ClassificationNA
--
--
--
--
--
--
--
--
C
Target OrganNA
--
--
--
--
--
--
--
--
NA
SpeciesNA
--
--
--
--
--
--
--
--
NA
StudyNA
--
--
--
--
--
--
--
--
NA
Biomonitoring Blood
--
--
--
--
--
--
--
--
--
--
Biomonitoring Urine
--
--
--
--
--
--
--
--
--
--
View Specific:Click here
--
--
--
--
--
--
--
--
Click here
*In mg/kg body weight per day, unless otherwise specified.


Cancer Oral Synopsis:

ATSDR and U.S. EPA have evaluated the carcinogenicity data for 1,1-dichloroethane. EPA classifies this chemical as C - possible human carcinogen. The cancer weight of evidence classification is based on all routes of exposure. ATSDR has published a Toxicological Profile for 1,1-Dichloroethane. Although ATSDR discusses the carcinogenicity data in its Toxicological Profiles, it does not currently assess cancer potency or perform cancer risk assessments.

The derivation of a biomonitoring equivalent (BE) was attempted by Aylward et al. (2010). However, no chemical-specific pharmacokinetic model was identified.

Cancer Oral Specifics:

ATSDR

PEER:
The ATSDR Toxicological Profile has undergone internal agency reviews and has been externally reviewed by a peer review panel.

MOREI:
ATSDR (Agency for Toxic Substances and Disease Registry). 2015. Toxicological Profile for 1,1-Dichloroethane. U.S. Department of Health and Human Services, Public Health Service. August. Available at http://www.atsdr.cdc.gov/ToxProfiles/tp.asp?id=718&;tid=129

For the list of ATSDR minimal risk levels (MRLs), see http://www.atsdr.cdc.gov/mrls/index.html

Cancer Oral Specifics:

U.S.EPA

MOREI:
Details on this chemical's assessment are available on U.S. EPA's Integrated Risk Information System (IRIS).

U.S. EPA. Integrated Risk Information System (IRIS). Online. National Center for Environmental Assessment, Washington, DC. Available on IRIS.

Aylward L.L., Kirman C.R., Blount B.C., Hays S.M. 2010. Chemical-specific screening criteria for interpretation of biomonitoring data for volatile organic compounds (VOCs) application of steady-state PBPK model solutions. Regul Toxicol Pharmacol. 2010 Oct;58(1):33-44. PubMed PMID: 20685286.


Noncancer Inhalation Risk Values Table:

ITER Noncancer Inhalation Risk Table for: DICHLOROETHANE, 1,1-
Risk Value Parameter OrganizationATSDRHealth CanadaIARCIPCSIPRVITER PRNSF IntlRIVMTCEQU.S.EPA
Risk Value Namechronic MRL
--
--
--
--
--
--
--
--
--
Risk Value*NA
--
--
--
--
--
--
--
--
--
Year2015
--
--
--
--
--
--
--
--
--
Base(Experimental)*NA
--
--
--
--
--
--
--
--
--
Basis(Adjusted)*NA
--
--
--
--
--
--
--
--
--
Uncertainty FactorNA
--
--
--
--
--
--
--
--
--
Critical Organ or EffectNA
--
--
--
--
--
--
--
--
--
SpeciesNA
--
--
--
--
--
--
--
--
--
StudyNA
--
--
--
--
--
--
--
--
--
Biomonitoring Blood
--
--
--
--
--
--
--
--
--
--
Biomonitoring Urine
--
--
--
--
--
--
--
--
--
--
View Specific:Click here
--
--
--
--
--
--
--
--
--
*In mg/kg body weight per day, unless otherwise specified.


Noncancer Inhalation Synopsis:

ATSDR has evaluated the noncancer inhalation toxicity data for 1,1-dichloroethane, but did not derive a chronic minimal risk level (MRL) because of uncertainties associated with identification of the most sensitive target and the associated concentration-response relationships.

Noncancer Inhalation Specifics:

ATSDR

PEER:
The ATSDR Toxicological Profile has undergone internal agency reviews and has been externally reviewed by a peer review panel.

MOREI:
ATSDR (Agency for Toxic Substances and Disease Registry). 2015. Toxicological Profile for 1,1-Dichloroethane. U.S. Department of Health and Human Services, Public Health Service. August. Available at http://www.atsdr.cdc.gov/ToxProfiles/tp.asp?id=718&;tid=129

For the list of ATSDR minimal risk levels (MRLs), see http://www.atsdr.cdc.gov/mrls/index.html


Cancer Inhalation Risk Values Table:

ITER Cancer Inhalation Risk Table for: DICHLOROETHANE, 1,1-
Risk Value Parameter OrganizationATSDRHealth CanadaIARCIPCSIPRVITER PRNSF IntlRIVMTCEQU.S.EPA
Risk Value NameNA
--
--
--
--
--
--
--
--
NA
Risk Value*NA
--
--
--
--
--
--
--
--
NA
Year2015
--
--
--
--
--
--
--
--
1990
ClassificationNA
--
--
--
--
--
--
--
--
C
Target OrganNA
--
--
--
--
--
--
--
--
NA
SpeciesNA
--
--
--
--
--
--
--
--
NA
StudyNA
--
--
--
--
--
--
--
--
NA
Biomonitoring Blood
--
--
--
--
--
--
--
--
--
--
Biomonitoring Urine
--
--
--
--
--
--
--
--
--
--
View Specific:Click here
--
--
--
--
--
--
--
--
Click here
*In mg/kg body weight per day, unless otherwise specified.


Cancer Inhalation Synopsis:

ATSDR and U.S. EPA have evaluated the carcinogenicity data for 1,1-dichloroethane. EPA classifies this chemical as C - possible human carcinogen. The cancer weight of evidence classification is based on all routes of exposure. ATSDR has published a Toxicological Profile for 1,1-Dichloroethane. Although ATSDR discusses the carcinogenicity data in its Toxicological Profiles, it does not currently assess cancer potency or perform cancer risk assessments.

The derivation of a biomonitoring equivalent (BE) was attempted by Aylward et al. (2010). However, no chemical-specific pharmacokinetic model was identified.

Cancer Inhalation Specifics:

ATSDR

PEER:
The ATSDR Toxicological Profile has undergone internal agency reviews and has been externally reviewed by a peer review panel.

MOREI:
ATSDR (Agency for Toxic Substances and Disease Registry). 2015. Toxicological Profile for 1,1-Dichloroethane. U.S. Department of Health and Human Services, Public Health Service. August. Available at http://www.atsdr.cdc.gov/ToxProfiles/tp.asp?id=718&;tid=129

For the list of ATSDR minimal risk levels (MRLs), see http://www.atsdr.cdc.gov/mrls/index.html

Cancer Inhalation Specifics:

U.S.EPA

MOREI:
Details on this chemical's assessment are available on U.S. EPA's Integrated Risk Information System (IRIS).

U.S. EPA. Integrated Risk Information System (IRIS). Online. National Center for Environmental Assessment, Washington, DC. Available on IRIS.

Aylward L.L., Kirman C.R., Blount B.C., Hays S.M. 2010. Chemical-specific screening criteria for interpretation of biomonitoring data for volatile organic compounds (VOCs) application of steady-state PBPK model solutions. Regul Toxicol Pharmacol. 2010 Oct;58(1):33-44. PubMed PMID: 20685286.

NO Revision History: