HSN: 53

NAME: GLYOXAL

CAS-RN: 107-22-2

DATE: 20180416

Risk Values - Summary Table

Summary Risk Table for:GLYOXAL
Risk Value Parameter OrganizationATSDRHealth CanadaIARCIPCSIPRVITER PRNSF IntlRIVMTCEQU.S.EPA
Oral: Non-Cancer
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--
--
green check
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--
--
--
--
--
Oral: Cancer
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--
--
green check
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--
--
--
--
--
Inhalation: Non-Cancer
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--
--
green check
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--
--
--
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--
Inhalation: Cancer
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green check
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--
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green check = Chemical evaluated and ITER data online.


Noncancer Oral Risk Values Table:

ITER Noncancer Oral Risk Table for: GLYOXAL
Risk Value Parameter OrganizationATSDRHealth CanadaIARCIPCSIPRVITER PRNSF IntlRIVMTCEQU.S.EPA
Risk Value Name
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TDI
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--
--
--
--
Risk Value*
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2E-1
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--
--
--
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Year
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--
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2003
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--
--
--
--
--
Base(Experimental)*
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--
NOAEL 100
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--
--
--
--
Basis(Adjusted)*
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--
--
NA
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--
--
--
--
--
Uncertainty Factor
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--
500
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--
--
--
--
Critical Organ or Effect
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--
--
multiple
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--
--
--
--
Species
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--
--
rat
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--
--
--
--
Study
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Soci t Fran aise Hoechst, 1987
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--
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Biomonitoring Blood
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--
--
--
--
--
--
--
--
Biomonitoring Urine
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--
--
--
--
--
--
--
--
View Specific:
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Click here
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*In mg/kg body weight per day, unless otherwise specified.


Noncancer Oral Synopsis:

IPCS has evaluated the noncancer oral toxicity data for glyoxal, and derived a tolerable daily intake (TDI) of 0.2 mg/kg-day based on a NOAEL of 100 mg/kg-day for a dose-related decrease of water and food consumption and body weight observed in a 28-day rat drinking water study (Société Française Hoechst, 1987). IPCS applied a total uncertainty factor of 500 (10 each for inter- and intraspecies differences and 5 for less-than-lifetime exposure).

Noncancer Oral Specifics:

IPCS

DCE:
See Sections 1 (Executive Summary) and 11.1 (Evaluation of Health Effects) in CICAD. Available at http://www.who.int/ipcs/publications/cicad/en/cicad57.pdf

QEST:
See Sections 1 (Executive Summary) and 11.1 (Evaluation of Health Effects) in CICAD. Available at http://www.who.int/ipcs/publications/cicad/en/cicad57.pdf

PEER:
This CICAD on glyoxal was prepared by the Fraunhofer Institute for Toxicology and Experimental Medicine, Hanover, Germany. It is based on reports compiled by the German Advisory Committee on Existing Chemicals of Environmental Relevance (BUA, 1997). Information on the preparation and peer review of the source document is presented in Appendix 1 of the CICAD. Information on the peer review of this CICAD is presented in Appendix 2. This CICAD was considered and approved as an international assessment at a meeting of the Final Review Board, held in Varna, Bulgaria, on 8-11 September 2003. Participants at the Final Review Board meeting are presented in Appendix 3 of the CICAD.

BIB:
BUA (1997) [Glyoxal.] German Chemical Society (GDCh) Advisory Committee on Existing Chemicals of Environmental Relevance (BUA). Stuttgart, S. Hirzel, Wissenschaftliche Verlagsgesellschaft, pp. 1-64 (BUA Report 187) (in German).

Société Française Hoechst (1987). Glyoxal 40. 28 day dose range finding study in rats by administration in drinking water. Unpublished report (Study No. 2619 TSR; HOE 87.1678) [cited in BUA, 1997].

MOREI:
IPCS (International Programme on Chemical Safety). 2004. Concise International Chemical Assessment Document 57: Glyoxal. Published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organization, and the World Health Organization, and produced within the framework of the Inter-Organization Programme for the Sound Management of Chemicals. World Health Organization, Geneva, Switzerland. Available at http://www.who.int/ipcs/publications/cicad/en/cicad57.pdf

For the full list of IPCS CICADs, see http://www.who.int/ipcs/publications/cicad/en/index.html


Cancer Oral Risk Values Table:

ITER Cancer Oral Risk Table for: GLYOXAL
Risk Value Parameter OrganizationATSDRHealth CanadaIARCIPCSIPRVITER PRNSF IntlRIVMTCEQU.S.EPA
Risk Value Name
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TD05
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--
--
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--
Risk Value*
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--
NA
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--
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Year
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--
--
2003
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--
--
--
--
--
Classification
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--
NA
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--
--
--
--
--
Target Organ
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NA
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--
--
--
--
--
Species
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--
NA
--
--
--
--
--
--
Study
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--
NA
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--
--
--
--
--
Biomonitoring Blood
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--
--
--
--
--
--
--
--
--
Biomonitoring Urine
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--
--
--
--
--
--
--
--
--
View Specific:
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--
Click here
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--
*In mg/kg body weight per day, unless otherwise specified.


Cancer Oral Synopsis:

IPCS has evaluated the oral carcinogenicity data for glyoxal, but did not conduct a quantitative cancer assessment. IPCS noted that glyoxal is directly genotoxic but gave mixed results in tumor-promotion assays.

Cancer Oral Specifics:

IPCS

PHC:
See Sections 1 (Executive Summary) and 11.1 (Evaluation of Health Effects) in CICAD. Available at http://www.who.int/ipcs/publications/cicad/en/cicad57.pdf

QEST:
See Sections 1 (Executive Summary) and 11.1 (Evaluation of Health Effects) in CICAD. Available at http://www.who.int/ipcs/publications/cicad/en/cicad57.pdf

PEER:
This CICAD on glyoxal was prepared by the Fraunhofer Institute for Toxicology and Experimental Medicine, Hanover, Germany. It is based on reports compiled by the German Advisory Committee on Existing Chemicals of Environmental Relevance (BUA, 1997). Information on the preparation and peer review of the source document is presented in Appendix 1 of the CICAD. Information on the peer review of this CICAD is presented in Appendix 2. This CICAD was considered and approved as an international assessment at a meeting of the Final Review Board, held in Varna, Bulgaria, on 8-11 September 2003. Participants at the Final Review Board meeting are presented in Appendix 3 of the CICAD.

BIB:
BUA (1997) [Glyoxal.] German Chemical Society (GDCh) Advisory Committee on Existing Chemicals of Environmental Relevance (BUA). Stuttgart, S. Hirzel, Wissenschaftliche Verlagsgesellschaft, pp. 1-64 (BUA Report 187) (in German).

MOREI:
IPCS (International Programme on Chemical Safety). 2004. Concise International Chemical Assessment Document 57: Glyoxal. Published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organization, and the World Health Organization, and produced within the framework of the Inter-Organization Programme for the Sound Management of Chemicals. World Health Organization, Geneva, Switzerland. Available at http://www.who.int/ipcs/publications/cicad/en/cicad57.pdf

For the full list of IPCS CICADs, see http://www.who.int/ipcs/publications/cicad/en/index.html


Noncancer Inhalation Risk Values Table:

ITER Noncancer Inhalation Risk Table for: GLYOXAL
Risk Value Parameter OrganizationATSDRHealth CanadaIARCIPCSIPRVITER PRNSF IntlRIVMTCEQU.S.EPA
Risk Value Name
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TC
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--
--
--
--
Risk Value*
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--
6E-3
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--
--
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Year
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2003
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--
--
--
--
--
Base(Experimental)*
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--
NOEL 0.6
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--
--
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--
Basis(Adjusted)*
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NA
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Uncertainty Factor
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100
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--
--
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Critical Organ or Effect
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larynx
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Species
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rat
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Study
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Hoechst AG, 1995
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Biomonitoring Blood
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--
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--
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Biomonitoring Urine
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--
--
--
--
--
--
--
--
View Specific:
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--
--
Click here
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--
--
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--
*In mg/kg body weight per day, unless otherwise specified.


Noncancer Inhalation Synopsis:

IPCS has evaluated the noncancer inhalation toxicity data for glyoxal, and derived a tolerable concentration (TC) in air of 0.006 mg/m3 based on a NOEL of 0.6 mg/m3 for local effects in the larynx observed in a 29-day rat inhalation study (Hoechst AG, 1995). IPCS applied a composite uncertainty factor of 100 (10 each for inter- and intraspecies variability).

Noncancer Inhalation Specifics:

IPCS

DCE:
See Sections 1 (Executive Summary) and 11.1 (Evaluation of Health Effects) in CICAD. Available at http://www.who.int/ipcs/publications/cicad/en/cicad57.pdf

QEST:
See Sections 1 (Executive Summary) and 11.1 (Evaluation of Health Effects) in CICAD. Available at http://www.who.int/ipcs/publications/cicad/en/cicad57.pdf

PEER:
This CICAD on glyoxal was prepared by the Fraunhofer Institute for Toxicology and Experimental Medicine, Hanover, Germany. It is based on reports compiled by the German Advisory Committee on Existing Chemicals of Environmental Relevance (BUA, 1997). Information on the preparation and peer review of the source document is presented in Appendix 1 of the CICAD. Information on the peer review of this CICAD is presented in Appendix 2. This CICAD was considered and approved as an international assessment at a meeting of the Final Review Board, held in Varna, Bulgaria, on 8-11 September 2003. Participants at the Final Review Board meeting are presented in Appendix 3 of the CICAD.

BIB:
BUA (1997) [Glyoxal.] German Chemical Society (GDCh) Advisory Committee on Existing Chemicals of Environmental Relevance (BUA). Stuttgart, S. Hirzel, Wissenschaftliche Verlagsgesellschaft, pp. 1-64 (BUA Report 187) (in German).

Hoechst AG (1995). Glyoxal 40\% (aqueous solution)  testing for subacute (29-days) inhalation toxicity in male and female Wistar rats. Frankfurt, Hoechst AG, Pharma Development, Corporate Toxicology (Unpublished Report No. 94.1056) [cited in BUA, 1997].

MOREI:
IPCS (International Programme on Chemical Safety). 2004. Concise International Chemical Assessment Document 57: Glyoxal. Published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organization, and the World Health Organization, and produced within the framework of the Inter-Organization Programme for the Sound Management of Chemicals. World Health Organization, Geneva, Switzerland. Available at http://www.who.int/ipcs/publications/cicad/en/cicad57.pdf

For the full list of IPCS CICADs, see http://www.who.int/ipcs/publications/cicad/en/index.html


Cancer Inhalation Risk Values Table:

ITER Cancer Inhalation Risk Table for: GLYOXAL
Risk Value Parameter OrganizationATSDRHealth CanadaIARCIPCSIPRVITER PRNSF IntlRIVMTCEQU.S.EPA
Risk Value Name
--
--
--
TC05
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--
--
--
--
--
Risk Value*
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--
--
NA
--
--
--
--
--
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Year
--
--
--
2003
--
--
--
--
--
--
Classification
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--
NA
--
--
--
--
--
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Target Organ
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--
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NA
--
--
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--
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Species
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--
--
NA
--
--
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--
--
--
Study
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--
NA
--
--
--
--
--
--
Biomonitoring Blood
--
--
--
--
--
--
--
--
--
--
Biomonitoring Urine
--
--
--
--
--
--
--
--
--
--
View Specific:
--
--
--
Click here
--
--
--
--
--
--
*In mg/kg body weight per day, unless otherwise specified.


Cancer Inhalation Synopsis:

IPCS has evaluated the inhalation carcinogenicity data for glyoxal, but did not conduct a quantitative cancer assessment due to lack of carcinogenicity studies by the inhalation route of exposure.

Cancer Inhalation Specifics:

IPCS

PHC:
See Sections 1 (Executive Summary) and 11.1 (Evaluation of Health Effects) in CICAD. Available at http://www.who.int/ipcs/publications/cicad/en/cicad57.pdf

QEST:
See Sections 1 (Executive Summary) and 11.1 (Evaluation of Health Effects) in CICAD. Available at http://www.who.int/ipcs/publications/cicad/en/cicad57.pdf

PEER:
This CICAD on glyoxal was prepared by the Fraunhofer Institute for Toxicology and Experimental Medicine, Hanover, Germany. It is based on reports compiled by the German Advisory Committee on Existing Chemicals of Environmental Relevance (BUA, 1997). Information on the preparation and peer review of the source document is presented in Appendix 1 of the CICAD. Information on the peer review of this CICAD is presented in Appendix 2. This CICAD was considered and approved as an international assessment at a meeting of the Final Review Board, held in Varna, Bulgaria, on 8-11 September 2003. Participants at the Final Review Board meeting are presented in Appendix 3 of the CICAD.

BIB:
BUA (1997) [Glyoxal.] German Chemical Society (GDCh) Advisory Committee on Existing Chemicals of Environmental Relevance (BUA). Stuttgart, S. Hirzel, Wissenschaftliche Verlagsgesellschaft, pp. 1-64 (BUA Report 187) (in German).

MOREI:
IPCS (International Programme on Chemical Safety). 2004. Concise International Chemical Assessment Document 57: Glyoxal. Published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organization, and the World Health Organization, and produced within the framework of the Inter-Organization Programme for the Sound Management of Chemicals. World Health Organization, Geneva, Switzerland. Available at http://www.who.int/ipcs/publications/cicad/en/cicad57.pdf

For the full list of IPCS CICADs, see http://www.who.int/ipcs/publications/cicad/en/index.html

NO Revision History: