|Range of the PFOA/S Safe Dose|
A coalition of interested parties is forming to develop a range in the safe dose(s) for perfluorooctanote (PFOA) and its sulfonic acid (PFOS), which is reflected in differences in safe doses world-wide of over 100,000-fold (see attached presentation). This collaboration started in September of 2022 with an open call for nominations to an advisory committee, now selected,* who will lead the coalition through a series of virtual and face-to-face and possibly in-person meetings. Results are anticipated in the Spring of 2023.
For interest in joining the coalition, please contact Michael Dourson at firstname.lastname@example.org
Keynote Presentation to the CleanUp Conference in Adelaide, Australia, and the Australian Government, Department of Health and Aged Care: Click Here
Range of the PFOA/S Safe Dose References: Click Here
Interactive Web-based and Email Discussion Click Here
To be developed.
To be developed.
Notes from Zoom-Call:
Notes of the Advisory Committee for International Collaboration on the PFOA/S Safe Doses
Lyle Burgoon, Raptor Pharm & Tox, Ltd, USA
Tony Cox, Cox Associates, USA
Summary of Discussions:
After introductions by members individually, Michael Dourson went over the ground rules for Alliance for Risk Assessment (ARA) projects. Briefly stated, ARA projects are to be focused on collaborative work where no party is excluded and all viewpoints are considered. Additionally, ARA projects are not to be used as a pretext for criticizing a single existing or developing organization’s position. With this particular project, several agency positions are found to be widely disparate (PFOA safe dose estimates are more than 100,000-fold apart), and so an international collaboration to attempt a narrowing of this range seems reasonable and well within the ARA framework.
At this point several members of the advisory group described findings of a previous international collaboration on PFOA human 1/2 life (see: https://tera.org/Alliance%20for%20Risk/Projects/pfoahumanhalflife.html). The prior effort was successful in reducing the credible range of the PFOA human ½ life 1 and has been cited in the recent WHO (2022)2 findings.
Next discussed was the process for the evaluation. The creation of three or perhaps four separate, and independent, science groups was proposed, based on the success of this approach with the previous international collaboration. Each group would be given identical tasks and instructions to work without discussion with other groups. Everyone agreed with this approach and also thought it best to address specific issues sequentially. Specific issues were determined to be mode(s) of action, choice of critical effect(s), method of extrapolation such as uncertainty factor, and data gaps. Periodic discussions among all groups was envision to share findings on specific issues and then to attempt a consensus.
Next discussed was the invitation for folks to assist. It was decided to send an invitation to already identified interested folks, and to make a broader announcement along these lines on social media. This general invitation would be followed by specific invitations to scientists known to be erudite in certain of the issues.
The time line for all of this work was recognized to vary depending on the issue under discussion. For example, discussion on the mode of action might be more easily done then that done on the critical effect. However, giving the science groups specific deadlines was considered important and would be determined at a subsequent advisory committee meeting. Interactions with outside parties was also considered to be important but premature at this call.
Finally, the committee thought that the listing of important references was needed and that the developing website should contain a section devoted to this, but perhaps organized by specific issue.
(1.) Campbell, Jerry, Harvey Clewell, Tony Cox, Michael Dourson, Shannon Ethridge, Norman Forsberg, Bernard Gadagbui, Ali Hamade, Ravi Naidu, Nathan Pechacek, Tiago Severo Peixe, Robyn Prueitt, Mahesh Rachamalla, Lorenz Rhomberg, James Smith, Nitin Verma. 2022. The Conundrum of the PFOA human half-life, an international collaboration. Regulatory Toxicology and Pharmacology 132 (2022) 105185.