Beyond Science and Decisions: From Issue Identification to Dose-Response Assessment

Workshop 2 Guest Speaker Presentations

Workshop Overview

Presentation by Ed Ohanian, U.S. Environmental Protection Agency (EPA). NRC findings and Current EPA Risk Assessment Forum Efforts

Presentation by Adam Finkel, University of Pennsylvania Law School & NAS Panelist. Beyond Misleading Underestimation of Carcinogenic Potency

Presentation by Peter Grevatt, Office of Children's Health Protection (No Slides; presentation on issues related to children's health)

Presentation by Craig Rowlands, The Dow Chemical Company. ILSI Risk21

Presentation by Doug Wolf, U.S. EPA National Health and Environmental Effects Research Laboratory. Dose Response Approaches for Nuclear Receptor Mediated Modes of Action Workshop Preliminary Report

Workshop 3 Guest Speaker Presentations

Workshop Overview

Rita Schoeny, Environmental Protection Agency. Experience at EPA in Problem Formulation Relevant to both Ecological and Human Dose-Response Analysis

Bette Meek, University of Ottawa. Increasing Assessment & Management Efficiency - The Importance of "Fit for Purpose" MOA/ Human Relevance Analysis

James Swenberg, University of North Carolina. Endogenous and Background DNA Adducts as a Means of Understanding Mode of Action (MOA) in the Low End of the Dose Response Curve

Resha Putzrath, U.S. Navy. Low-Dose Linearity for Noncancer Risks and Dose Additivity for Mixtures

 

Case Studies

Case studies were presented at Workshops II & III. In some instances, studies presented at Workshop II were revised and the enhanced case studies were presented at Workshop III. In such situations, the both the "initial" and the "revised" presentations are provided below.


Panel Discussion Questions

 

Lead – Dose-response relationship for effect on Children’s IQ
Carrington C.D.

Background/Endogenous Damage: Considerations for Dose-Response & Risk Assessment
Pottenger L.H., Bus J.S., with support from J.A. Swenberg

Comparison of Hattis strawman approach and BMDs/UFs for noncancer endpoints (carbonyl sulfide and tetrachlorobenzene)
Greco S.L., Hattis D.H., Lynch M.K.

Quantitative Assessment of Sensitivity and Variability in Humans: Modeling the Effects of Low Dose Exposure to Dietary Residues of Chlorpyrifos   
Juberg D.R., Price P.

Risk Assessment of Exposure to Trihalomethane Drinking Water Disinfection By-Products.  Use of Biomonitoring Equivalents and Biomonitoring Data from NHANES
Aylward L.L., Hays S.M., Kirman C.R., Becker RA


Risk-Risk Comparison:  Comparative Risk for Use of Perchloroethylene (Perc) or N-propyl-bromide (NPB) in Dry Cleaning
Clewell H., Finkel A.

BBDR model for respiratory tract carcinogenicity of inhaled formaldehyde
Allen B., Clewell H., Conolly R., Haney J., Kester J.

Inititial Case Study

Revised Case Study

Assessment of Low-Dose Dose-Response Relationships (Non-linear or Linear) for Genotoxicity, Focused on Induction of Mutations & Clastogenic Effects
Moore M., Pottenger L., Zeiger E., and Zhou T.

Initial Case Study

Revised Case Study

Implications of Linear Low-Dose Extrapolation from Benchmark Dose for Noncancer Risk Assessment
Kroner O., Haber L.
Advisor: Dourson M.
Initial Case Study Revised Case Study
Framework for Evaluating Alternative Temporal Patterns of Exposure for Risk Characterization
Maier A., Haber L., Haney J., Kaden D.A., Carrier R., Craft E., and Hertzberg R.
Advisor: Dourson, M.
Initial Case Study

Revised Case Study

 

Review and application of data fusion methodologies for toxicological dataset analysis to resolve data quality issues in predictive toxicology and contaminated sites risk assessment.
Mohapatra A.K., Sadiq R., Zargar A., Islam S., Dyck R.

Initial Case Study

Revised Case Study

 

Use of human data in cancer risk assessment of chemicals as illustrated by the case of 1,3-Butadiene
Albertini R., Sielken Jr. R.L.

Initial Case Study Revised Case Study

The Quantitative Human Health Risk Assessment for 1,3-Butadiene Based Upon Ovarian Effects in Rodents
Kirman C.R., Grant R.L.

Initial Case Study

Revised Case Study

Apply AEGL Methodology to Develop Acute Exposure Guideline Levels for Ethylbenzene
Grant R., Erraguntla N., Hinz J., Camacho I.A.

Initial Case Study

Revised Case Study

Deriving Health-Protective Values for Evaluation of Acute Inhalation Exposures for Chemicals with Limited Toxicity Data Using a Tiered Screening Approach
Grant R.L., Phillips T., Ethridge S.

Initial Case Study

 

Consideration of Human Kinetic Variability
Lipscomb J.C., Teuschler L.K., Swartout J., Popken D., Cox T., Kedderis G.L.

Initial Case Study

 

Multiple modes of action and risk assessment modeling
Hertzberg R.
Advisor: Dourson M.

Initial Case Study

Application of National Research Council “Silverbook” Methodology for Dose Response Assessment of 2,3,7,8-Tetrachlorodibenzo(p)dioxin.
Simon T., Stephens M., Yang Y., Manning R.O., Budinsky R.A. and Rowlands J.C.

Intial Case Study

Revised Case Study

Estimate Risk Above the RfD Using Uncertainty Factor Distributions
Spalt E., Kroner O.
Advisor: Dourson M.

Initial Case Study

Revised Case Study

Use of biomarkers in the benchmark dose method
Gentry R., Van Landingham C., Hays S., Aylward L.

Initial Case Study

Revised Case Study

Sustainable Futures Screening
Becker E., Ranslow P.

Initial Case Study

Revised Case Study

Biologically-Informed Empirical Dose Response Modeling:  Using Linked Cause-Effect Functions to Extend the Dose-Response Curve to Lower Doses (Titanium dioxide - TiO2)
Allen B., Maier A., Willis A., Haber L.T.

Initial Case Study

Ethanol Case Study Evaluating Human Dose-Response of Morbidity and Mortality from Hepatic Disease: Are the Predicted Risks from Low-Dose Linear Extrapolation to Environmentally Relevant Concentrations Biologically Plausible?
Becker R., Hays S.

Initial Case Study

Revised Case Study

Use of Categorical Regression – Risk Above the RfD
Danzeisen R., Krewski D., Chambers A., Baker S., Hertzberg R., and Haber L.

Initial Case Study

Revised Case Study
 

 

 

For more information, please contact Oliver Kroner.