Dose-Response Assessment Boot Camp





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Current Courses



5-Day Course - September 24 - 28 2018, Cincinnati, Ohio - REGISTER NOW!


Dose-Response Assessment Boot Camp

It is an intensive, in-depth hands-on training in hazard characterization and dose-response assessment for human health risk assessments. This week-long course with emphasis on dose response assessment is based on our popular chemical risk assessment training sessions developed and presented to various audiences in the past decade. It is designed to provide systematic training in current assessment practices as well as in the latest methods in human health chemical risk assessments.  The course is for beginners through experienced toxicological risk   assessors who wish to learn advanced methods and enhance their understanding and skills in the basics.  The students will learn all aspects of hazard characterization and dose response assessment, and practice the skills learned in the classroom.  Upon completing the course, the participants will be able to derive and evaluate risk values and supporting documentation for non-cancer and cancer risk assessments and will receive a certificate documenting their successful completion of the course.  Five Certification Management (CM) points are available from the American Board of Industrial Hygienists (ABIH).   It is also worth 4 Continuing Education Units (CEU).  Click here for the course brochure.


This course is endorsed by the Society of Toxicology (SOT).

And a recognized event by the Society for Risk Analysis (SRA).


Current Courses



5-Day Course: September 24 -28, Cincinnati, Ohio


This course will be held September 24 -28 2018, in Cincinnati, Ohio at the Children’s Hospital Offices of Vernon Place, Drug & Poison Information Center Floor 2, 2905 Vernon Place  45229.

. The course run from 8:00am-5:00pm Monday-Thursday, and 8:00am-2:00pm Friday. Accommodations to be announced.




Course Fee

Regular Registration.... $2300 (Federal Agency, Industry, University, etc) / $1800 (State/Local/Tribal Agencies)

LATE Registration, after August 24 2018: $2500 (Federal Agency, Industry, University, etc) / $2000 (State/Local/Tribal Agencies)

Course fee includes
• Tuition
• Take home reference binder
• Morning and afternoon breaks
• Certificate of completion

Payment Policy
Registration is accepted on a first come, first served basis. Full payment (in US funds) must be received in order to process your registration. To register, please mail or fax (513-488.1990) the enclosed registration form with credit card information or check/money order (payable to TERA) to: Boot Camp Registration, TERA, 1250 Ohio Pike, Suite 197, Cincinnati, OH 45102.. Please contact Valerie at or 513-542- 7475 x 104 with questions.


Cancellation/Substitution Policy
Cancellations made on or before July 22, 2018 will be issued a refund less a $150 administrative fee per person | Cancellations received between July 25, 2018 and September 4, 2018 will be issued a 50% refund | No refunds will be issued after September 4, 2018.
Substitutions are allowed with a $50 administrative fee per person, but must be made by Tuesday, September 4, 2018 | Requests for substitutions or cancellations must be made in writing, via email to Valerie Ayers at


In the event the course is cancelled for the listed dates, registered attendees can either request a full refund of the course registration fee or apply it to the next course which would be schedule within 6-12 months of the original course date.



Accommodations to be announced


General Course Information


Who should attend?

bullet Risk assessors and toxicologists who conduct and write chemical assessments 

bullet Risk assessors and toxicologists who review chemical assessments  

bullet Risk managers or policymakers who use the results of chemical assessments and want to fully understand the processes involved in risk value development


Participant requirements

bullet A basic understanding of toxicology    

bullet An interest in developing their skills in human health risk assessment


What you will learn 


1 Non-cancer and Cancer Risk Assessment Principles and Methods Learn how to  critically analyze effect data, understand toxicokinetic data and their use in understanding mode of action (MOA) and developing risk values. Learn how to incorporate uncertainty factors, utilize frameworks for considering MOA and human  relevance, and learn information synthesis approaches for hazard characterization and critical study identification, and calculation of risk values for non-cancer (e.g., reference doses or tolerable intakes) and cancer endpoints (e.g., cancer slope factors). Learn the latest methodologies used in dose-response assessment. 


 2.  Dosimetric Adjustment Methods in Dose Response Learn how to develop interspecies oral dose adjustments for non-cancer and cancer assessment, cancer unit risk or slope factor conversion, inhalation exposure concentration unit conversion, and human equivalent concentration (HEC) calculation for particle and vapor exposure using various modeling approaches.  Applications of the results of physiologically-based pharmacokinetic (PBPK) modeling will also be introduced. 


3.  Benchmark Dose (BMD) Modeling and Application in Risk Assessment:   Learn how to do BMD modeling for non-cancer and cancer dose-response assessments and get hands-on experience using the latest EPA software.  Learn how to appropriately apply BMD modeling, choose models and parameters, select data and run models, and select the appropriate BMD as a point of departure in a human health risk assessment.  The course addresses all of the models in the EPA software, including dichotomous continuous, cancer, and nested models.


4.  Principles for the Application of Uncertainty Factors and Chemical Specific Adjustment Factor (CSAF) Methodology: Learn the concept of uncertainty factors and how they are used in non-cancer risk and safety assessment by USEPA and other organizations, and how data are used to   support values other than defaults.  Learn how to develop and use CSAFs according to the methods of the International Programme on Chemical Safety (IPCS), which includes the use of mechanistic and toxicokinetic data to replace default uncertainty factors for interspecies extrapolation and intraspecies variability in deriving risk values such as RfDs and Tolerable Concentrations (TCs).   


5.  Comprehensive Risk Assessment Practice Learn to develop, present and review a comprehensive non-cancer and cancer assessment for a complex sample chemical over the course of the entire week.



Boot Camp Software


Below are the links for thesoftware you will need on your laptop for the Boot Camp Course. 

RDDR (zip file, although this is EPA software, it is older software and not available on the EPA website)

MPPD - (this link takes you to a registration form that you must complete to receive an email with the link to the software)

U.S. EPA's Benchmark Dose Software (takes you to the USEPA's page for the software, you can register to receive updates or skip the registration)



Look at the Frequently Asked Questions for more details or for more information, please contact Dr. Michael Dourson at 513-542-7475 x105 or


Dose - Response Assessment Boot Camp is a registered trademark of Toxicology Excellence for Risk Assessment (TERA).