Dose-Response Assessment Boot Camp


Boot Camp course May 06-10 2024.



Current course informational Brochure PDF Version or view the Online version Click Here



Lunch is provided for all days of the Boot Camp course.






Print the Registration Form Click Here



Click Here for accommodation information and to book rooms.



Endorsement Pending:
Endorsed Pending:



Dose-Response Assessment Boot Camp

It is an intensive, in-depth hands-on training in hazard characterization and dose-response assessment for human health risk assessments. This week-long course with emphasis on dose response assessment is based on our popular chemical risk assessment training sessions developed and presented to various audiences in the past decade. It is designed to provide systematic training in current assessment practices as well as in the latest methods in human health chemical risk assessments.  The course is for beginners through experienced toxicological risk   assessors who wish to learn advanced methods and enhance their understanding and skills in the basics.  The students will learn all aspects of hazard characterization and dose response assessment, and practice the skills learned in the classroom.  Upon completing the course, the participants will be able to derive and evaluate risk values and supporting documentation for non-cancer and cancer risk assessments and will receive a certificate documenting their successful completion of the course.  Five Certification Management (CM) points are available from the American Board of Industrial Hygienists (ABIH).   It is also worth 4 Continuing Education Units (CEU).  Click here for the course brochure.



Current Courses



5-Day Course: May 06-10 2024, Cincinnati, Ohio


This course will be held in Cincinnati, Ohio at the Historic Enquirer Building


The course runs from 8:00am-5:00pm Monday-Thursday, and 8:00am-2:00pm Friday.


Click Here for accommodation information and to book rooms.




Course Fee

Regular Registration.... $2750 (Federal Agency, Industry, University, etc) / $2250 (State/Local/Tribal Agencies)

LATE Registration: $2950 (Federal Agency, Industry, University, etc) / $2450 (State/Local/Tribal Agencies) (If received after April 5,, 2024)

Course fee includes
• Tuition
• Digital copy of the reference binder
• Morning and afternoon breaks
• Lunch
• Certificate of completion

Payment Policy
Registration is accepted on a first come, first served basis. Full payment (in US funds) must be received in order to process your registration. To register, please mail or fax (513-488.1990) the enclosed registration form with credit card information or check/money order (payable to TERA) to: Boot Camp Registration, TERA, 1250 Ohio Pike, Suite 197, Cincinnati, OH 45102.. Please contact Valerie at or 513-542- 7475 x 104 with questions.


Cancellation/Substitution Policy
Cancellations made on or before March 1, 2024 will be issued a refund less a $250 administrative fee per person | Cancellations received between March 2, 2024 and April 1, 2024 will be issued a 50% refund | No refunds will be issued after April 1, 2024.
Substitutions are allowed with a $120 administrative fee per person, but must be made by March 31, 2024| Requests for substitutions or cancellations must be made in writing, via email to Valerie Ayers at


In the event the course is cancelled for the listed dates, registered attendees can either request a full refund of the course registration fee or apply it to the next course which would be schedule within 6-12 months of the original course date.



Click Here


General Course Information


Who should attend?

bullet Risk assessors and toxicologists who conduct and write chemical assessments 

bullet Risk assessors and toxicologists who review chemical assessments  

bullet Risk managers or policymakers who use the results of chemical assessments and want to fully understand the processes involved in risk value development


Participant requirements

bullet A basic understanding of toxicology    

bullet An interest in developing their skills in human health risk assessment


What you will learn 


1 Non-cancer and Cancer Risk Assessment Principles and Methods Learn how to  critically analyze effect data, understand toxicokinetic data and their use in understanding mode of action (MOA) and developing risk values. Learn how to incorporate uncertainty factors, utilize frameworks for considering MOA and human  relevance, and learn information synthesis approaches for hazard characterization and critical study identification, and calculation of risk values for non-cancer (e.g., reference doses or tolerable intakes) and cancer endpoints (e.g., cancer slope factors). Learn the latest methodologies used in dose-response assessment. 


 2.  Dosimetric Adjustment Methods in Dose Response Learn how to develop interspecies oral dose adjustments for non-cancer and cancer assessment, cancer unit risk or slope factor conversion, inhalation exposure concentration unit conversion, and human equivalent concentration (HEC) calculation for particle and vapor exposure using various modeling approaches.  Applications of the results of physiologically-based pharmacokinetic (PBPK) modeling will also be introduced. 


3.  Benchmark Dose (BMD) Modeling and Application in Risk Assessment:   Learn how to do BMD modeling for non-cancer and cancer dose-response assessments and get hands-on experience using the latest EPA software.  Learn how to appropriately apply BMD modeling, choose models and parameters, select data and run models, and select the appropriate BMD as a point of departure in a human health risk assessment.  The course addresses all of the models in the EPA software, including dichotomous continuous, cancer, and nested models.


4.  Principles for the Application of Uncertainty Factors and Chemical Specific Adjustment Factor (CSAF) Methodology: Learn the concept of uncertainty factors and how they are used in non-cancer risk and safety assessment by USEPA and other organizations, and how data are used to   support values other than defaults.  Learn how to develop and use CSAFs according to the methods of the International Programme on Chemical Safety (IPCS), which includes the use of mechanistic and toxicokinetic data to replace default uncertainty factors for interspecies extrapolation and intraspecies variability in deriving risk values such as RfDs and Tolerable Concentrations (TCs).   


5.  Comprehensive Risk Assessment Practice Learn to develop, present and review a comprehensive non-cancer and cancer assessment for a complex sample chemical over the course of the entire week.



Boot Camp Software


Below are the links for thesoftware you will need on your laptop for the Boot Camp Course. 

RDDR is no longer supported



MPPD - (this link takes you to a registration form that you must complete to receive an email with the link to the software)


If you are experience issues getting the software click here to download the file and save it to your laptop. (NOTE: You will need a third-party software to unzip the file like 7-Zip or PC-Unzip. Some versions of Windows can unzip natively. This is a third-party software and TERA does not provide support other than basic installation. This software WILL NOT run on any Apple product without a Parallel desktop running Windows.


You need ADMINISTRATIVE rights to use the software

U.S. EPA's Benchmark Dose Software
(takes you to the USEPA's page for the software, you can register to receive updates or skip the registration)



Look at the Frequently Asked Questions for more details or for more information, please contact Dr. Bernard Gadagbui at 513-542-7475 x104 or


Dose - Response Assessment Boot Camp is a registered trademark of Toxicology Excellence for Risk Assessment (TERA).