The Conundrum of the PFOA Human Half-life


A coalition of interested parties is being formed to explore and possibly resolve the conundrum in human 1/2 life for perfluorooctanote (PFOA), which is reflected in differences in safe doses world-wide of 750-fold (Mikkonen et al., 2020).  A recent paper has been submitted that addresses this conundrum in part (Dourson and Gadagbui, 2021).  This collaboration started in April of 2021 with nominations to an advisory committee* who will then lead the coalition through a series of virtual and possibly face-to-face meetings, with conclusions expected later this year.   Toxicology Excellence for Risk Assessment ( has been designated as the nonprofit organization to support this coalition by the ARA Steering Committee (  Because TERA is a 501c3 nonprofit organization, all donations to this effort are tax deductible. 


For interest in joining the coalition, please contact Michael Dourson at


*Advisory Committee:

  • Harvey Clewell, Ramboll 
  • Tony Cox, Cox and Associates
  • Michael Dourson, Toxicology Excellence for Risk Assessment
  • Shannon Ethridge, International Association of Plumbing and Mechanical Officials
  • Ali Hamade, Oregon Health Authority
  • Ravi Naidu, Cooperative Research Centre for Contamination Assessment and Remediation of the Environment
  • Nitin Verma, Chitkara University


*PFOA Human Half-life References: Click Here


Notes of May 26/27 International Zoom-Call: Advisory Committee for the ARA PFOA 1/2 Life Project


Present: Harvey Clewell, Tony Cox, Michael Dourson, Shannon Ethridge,  Ali Hamade, Ravi Naidu, and Nitin Verma


Agenda items and notes:

    • Involving other interested groups or scientists: ARA projects are an open “sandbox."  Any interested scientist/manager is welcome to join.  The Advisory Committee should feel free to "cast its net" widely.
    • Procuring additional published papers: Committee members were requested to add relevant papers to the ones on the list available at  These papers will form the basis of discussions for resolution of the relevant issues.
    • Getting the work done: After a brief discussion, it was proposed to get the work done in the following manner:
        • Form several groups of 3 or maybe 4 scientists who would independently review the list of relevant references during the summer and form some initial conclusions;
        • Get these groups of scientists together for an initial discussion of conclusions likely in September, with the development of refined and/or consensus conclusions;
        • Have an open meeting in October to discussed these refined and/or consensus conclusions where government authorities (and others) are invited to offer additional suggestions;
        • Have an open meeting at the Society for Risk Analysis annual meeting in December to go over penultimate consensus conclusions and to receive additional suggestions for improvement;
        • Submit findings to a journal for independent peer review and publication, or alternatively, conduct an independent peer review meeting.
    • Many, if not all, of these meetings may be doable by zoom or webinar arrangements, so the overall cost above volunteered time may not be significant.  Furthermore, zoom meetings might allow more government participation and avoid the hassles of travel reimbursement.  However, part of getting this project done might also involve procuring donations.  Outside groups, such as the Center for Truth in Science, could be approached for guidance. 
    • Good and Welfare:  CRC Care will be have a large conference on PFAS chemistries in September of 2022.  


Action Items: Advisory Committee members should...

    • Send names and contact information for any scientist/manager potentially interested in this project to Michael Dourson to get on the weekly or biweekly email update.  Committee members should feel free to forward these weekly or biweekly mails to anyone else that might be interested.
    • Think of scientists who might be willing to work in small teams (3 or maybe 4 folks) to review the developing list of papers (current list at and send these names to the rest of the team for further discussion.
    • Identify critical issues associated with this project and send them to the rest of the team for further discussion.


Notes of June 15/16 International Conference Zoom Call

Present: Jerry Campbell (for Harvey Clewell), Tony Cox, Michael Dourson, Shannon Ethridge,  Ali Hamade, Ravi Naidu, and Nitin Verma

Agenda items and notes:

  • Discussion of small group nominees: Eleven nominations were received from a variety of sectors and varied expertise.  After a brief discussion, all nominees, shown below, were accepted.  Additional nominations would be welcome over the next week or so, and several members of the advisory committee will fill in as needed to create 4 groups of 4 folks each.
      • Neeraja Erraguntla, American Chemistry Council
      • Norman Forsberg, Arcadis
      • Bernard Gadagbui, Toxicology Excellence for Risk Assessment
      • Enoch Ledet, Product Assurance, LLC
      • Marc Nascarella, Massachusetts Department of Public Health
      • Nathan Pechack, Ecolab
      • Tiago Severo Peixe, University of Londrina
      • Robyn Pruitt, Gradient
      • Mahesh Rachamalla, University of Saskatchewan
      • Lorenz Rhomberg, Gradient
      • James Smith, Navy and Marine Corps Public Health Center


  • Charge to the working groups: The charge is to be simple and direct with a lot of lattitude given to small groups for their work.  After some discussion, the charge was determined to be:
      • Select studies from the current list for further review and explain why certain studies were excluded.  Feel free to add studies as appropriate and explain why they were added.
      • Develop a group consensus on PFOA 1/2 life, discussing critical issues, such as, volume of distribution, 1/2 lives in different populations, and how uncertainty factors for experimental animal to human extrapolation and within human variability are affected.  Groups are free to add critical issues as appropriate.
      • No inter-group discussions are allowed as to avoid premature closure.
      • The deadline is August 31st for this first round of review.
  • The second round of review will occur sometime in September/October for the purpose of forming a consensus among all 4 groups.  Interested outside scientists and managers will be invited to participate.
  • Round 3 is not yet envisioned although the Society for Risk Analysis annual meeting may be a good venue.
  • Adding papers to the existing list: Several groups have analyzed the clinical study on PFOA by Elcombe et al. (2013), which was submitted as a patent application.  The patent application was considered to be a good addition to the current list of papers.  A marked version of this will be added to the list.
  • A session at the Society for Risk Analysis session (in December, 2021) was considered to be a good venue for displaying the current version of this effort.  A proposal will be considered by the June 30 deadline.
  • Good and Welfare: The cicada invasion in the eastern US is waning.  Australian has few if any COVID cases!



Project Contact:
Dr. Michael Doursoni

Interested Partners:



Hull and Associates