A coalition of interested parties is forming to develop a range in the safe dose(s) for perfluorooctanote (PFOA) and its sulfate (PFOS), which is reflected in differences in safe doses world-wide of over 100,000-fold (see attached presentation). This collaboration started in September of 2022 with an open call for nominations to an advisory committee, now selected,* who will lead the coalition through a series of virtual and face-to-face and possibly in-person meetings. Results are anticipated in the Spring of 2023.
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Beyond Science and Decisions: From Problem Formulation to Dose-Response Assessment Workshop XIV
Since 2010, the Alliance for Risk Assessment (ARA) has sponsored a workshop series titled Beyond Science & Decisions: From Problem Formulation to Comprehensive Risk Assessment. Building on the ideas of the National Academy of Sciences' (NAS) Science & Decisions: Advancing Risk Assessment (2009), twelve previous workshops brought together over 60 organizations seeking to advance the NAS recommendations.
Over 50 presented case studies have thus far contributed to an expanding compendium of practical, problem-driven approaches for “fit for purpose” risk assessments. As a resource for regulators and scientists, the compendium details key considerations for applying relevant dose-response or exposure assessment methods, whether novel or evolving, and links these methods to specific problems faced by risk assessors and risk managers in a variety of organizations (e.g., local, regional and federal governments, academia, private sector).
Featured Project: The Conundrum of the PFOA Human Half-life
A coalition of interested parties is being formed to explore and possibly resolve the conundrum in human 1/2 life for perfluorooctanote (PFOA), which is reflected in differences in safe doses world-wide of 750-fold (Mikkonen et al., 2020). A recent paper has been submitted that addresses this conundrum in part (Dourson and Gadagbui, 2021). This collaboration started in April of 2021 with nominations to an advisory committee* who will then lead the coalition through a series of virtual and possibly face-to-face meetings, with conclusions expected later this year. Toxicology Excellence for Risk Assessment (www.tera.org) has been designated as the nonprofit organization to support this coalition by the ARA Steering Committee. Because TERA is a 501c3 nonprofit organization, all donations to this effort are tax deductible.