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Next Class

May 5-9, 2025. Location, Hampton Inn Cincinnati, Ohio.

Register Now:

  • Online Registration for General $2300 USD
    CLICK HERE to Register
  • BCRegAll.htmlOnline Registration for State / Local / Tribal $1950 USD
    CLICK HERE to Register
  • Register via the print form and email it to ayers@tera.org
    CLICK HERE to Register

Course fee includes

• Tuition
• Digital copy of the reference binder
• Morning and afternoon breaks
• Lunch
• Certificate of completion

Event Location Information Click Here

Payment Policies Click Here

Boot Camp Policies

Payment Policy
Registration is accepted on a first come, first served basis. Full payment (in US funds) must be received in order to process your registration. To register, please mail or fax (513-488.1990) the enclosed registration form with credit card information or check/money order (payable to TERA) to: Boot Camp Registration, TERA, 1250 Ohio Pike, Suite 197, Cincinnati, OH 45102.. Please contact Valerie at ayers@tera.org or 513-542- 7475 x 104 with questions.

Cancellation/Substitution Policy
Cancellations made on or before March 15, 2025 will be issued a refund less a $250 administrative fee per person | Cancellations received between March 16-31, 2025 will be issued a 50% refund | No refunds will be issued after April 1, 2025.
 
Substitutions are allowed with a $120 administrative fee per person, but must be made by April 15, 2025. Requests for substitutions or cancellations must be made in writing, via email to Valerie Ayers at ayers@tera.org.

In the event the course is cancelled for the listed dates, registered attendees can either request a full refund of the course registration fee or apply it to the next course which would be schedule within 6-12 months of the original course date.

Accommodation information Click Here

General Course Information

Who should attend?

bullet Risk assessors and toxicologists who conduct and write chemical assessments 

bullet Risk assessors and toxicologists who review chemical assessments  

bullet Risk managers or policymakers who use the results of chemical assessments and want to fully understand the processes involved in risk value development

Participant requirements

bullet A basic understanding of toxicology    

bullet An interest in developing their skills in human health risk assessment

What you will learn 

1.  Non-cancer and Cancer Risk Assessment Principles and Methods:  Learn how to  critically analyze effect data, understand toxicokinetic data and their use in understanding mode of action (MOA) and developing risk values. Learn how to incorporate uncertainty factors, utilize frameworks for considering MOA and human  relevance, and learn information synthesis approaches for hazard characterization and critical study identification, and calculation of risk values for non-cancer (e.g., reference doses or tolerable intakes) and cancer endpoints (e.g., cancer slope factors). Learn the latest methodologies used in dose-response assessment. 

 2.  Dosimetric Adjustment Methods in Dose Response:  Learn how to develop interspecies oral dose adjustments for non-cancer and cancer assessment, cancer unit risk or slope factor conversion, inhalation exposure concentration unit conversion, and human equivalent concentration (HEC) calculation for particle and vapor exposure using various modeling approaches.  Applications of the results of physiologically-based pharmacokinetic (PBPK) modeling will also be introduced. 

3.  Benchmark Dose (BMD) Modeling and Application in Risk Assessment:   Learn how to do BMD modeling for non-cancer and cancer dose-response assessments and get hands-on experience using the latest EPA software.  Learn how to appropriately apply BMD modeling, choose models and parameters, select data and run models, and select the appropriate BMD as a point of departure in a human health risk assessment.  The course addresses all of the models in the EPA software, including dichotomous continuous, cancer, and nested models.

4.  Principles for the Application of Uncertainty Factors and Chemical Specific Adjustment Factor (CSAF) Methodology: Learn the concept of uncertainty factors and how they are used in non-cancer risk and safety assessment by USEPA and other organizations, and how data are used to   support values other than defaults.  Learn how to develop and use CSAFs according to the methods of the International Programme on Chemical Safety (IPCS), which includes the use of mechanistic and toxicokinetic data to replace default uncertainty factors for interspecies extrapolation and intraspecies variability in deriving risk values such as RfDs and Tolerable Concentrations (TCs).   

5.  Comprehensive Risk Assessment Practice:  Learn to develop, present and review a comprehensive non-cancer and cancer assessment for a complex sample chemical over the course of the entire week.

TERA updates training materials before each course. Materials are then submitted to SOT and SRA for review as endorsements are provided on an individual course basis.

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Brochure

Current course informational Brochure PDF Version or view the Online version Click Here or Scan the QRcode to view on your phone or tablet

Got Questions?

Watch the video below for the most common question people have about TERA’s Dose-Response Assessment Boot Camp.

Software You Will Need

Below are the links for the software you will need on your laptop for the Boot Camp Course. You may need to contact you IT department to get the software installed.

NOTE: Mac devices are not supported.

MPPD –https://www.ara.com/mppd/ (this link takes you to a registration form that you must complete to receive an email with the link to the software) You need JAVA 7or above and it must be the 32bit version (the 64bit version will not work).

If you are experience issues getting the software click here to download the file and save it to your laptop. (NOTE: You will need a third-party software to unzip the file like 7-Zip or PC-Unzip. Some versions of Windows can unzip natively. This is a third-party software and TERA does not provide support other than basic installation. This software WILL NOT run on any Apple product without a Parallel desktop running Windows.

You need ADMINISTRATIVE rights to use the software


U.S. EPA’s Benchmark Dose Software (takes you to the USEPA’s page for the software, you can register to receive updates or skip the registration)

If you have additional questions or need more information, please contact Dr. Bernard Gadagbui at 513-542-7475 x104 or gadagbui@tera.org

Dose - Response Assessment Boot Camp is a registered trademark of
Toxicology Excellence for Risk Assessment (TERA).

Corporate Info

Resources

Our Brands

  • ITER ITER

Contacts

  • 1250 Ohio Pike, Suite 197, Cincinnati Ohio 45102
  • 513.488.1990
  • TERA@TERA.ORG

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WEEL OEL

Occupational Exposure Limits (OELs) are designed to safeguard the health of healthy workers during their careers. These limits are based on the assumption of repeated daily exposure throughout a working lifetime, typically averaged over an 8-hour workday. Their purpose is to prevent both immediate (acute) and long-term (chronic) health issues arising from workplace exposures. It’s important to note that OELs are not intended for the general public, which includes vulnerable groups like infants, the elderly, and those with pre-existing health conditions.

Workplace Environmental Exposure Levels (WEELs) are health-based guidelines for chemical hazards in the workplace. These values represent air concentrations believed to protect the majority of workers from negative health effects resulting from occupational chemical exposure.

The WEEL Process
Click Here

The development of new or revision of existing WEELs is typically assigned to voluntarily designated subcommittees. A subcommittee usually comprises 3 – 4 members from the WEEL Committee. New WEELs are developed using the OARS-WEEL administrative standard operating procedure (SOP), while existing WEELs are usually revised every 10 years, unless the availability of significant new data which may impact the existing WEEL value compels the committee to make a revision sooner. The OARS-WEEL SOP contains procedures and guidelines governing conflicts of interest, draft document preparation, literature searches, draft document review, balloting process, post-ballot WEEL documentation quality assurance scientific review, and publication.

Once a subcommittee has prepared a draft WEEL document, a review of the draft is scheduled for the next available Committee meeting. The WEEL Committee members are expected to have reviewed all such drafts prior to the meeting. If no major changes are necessary to a draft, the attending Committee membership may, by a simple majority, approve the WEEL for balloting. Alternatively, the Committee may direct the subcommittee to revise the WEEL and present it for further discussion at a future meeting. If a ballot is not approved by a two-thirds majority of non-abstaining Committee members, it is discussed at the next Committee meeting to determine the appropriate course of action. Once the WEEL is approved by a two-thirds majority of non-abstaining Committee members, copies of ballot comments are forwarded to the designated subcommittee and all substantive comments must be addressed in the final draft. If resolution of a substantive comment results in a change to the WEEL value or a change in the basis for the value, the draft must be re-balloted.

Once all comments have been addressed on a successfully balloted draft, document formatting and editorial review are performed by TERA, before the draft WEEL document is made available for public comment (usually for a period of 30 days but may be extended if the need arises). After the public comment period has elapsed, comments are addressed by the subcommittee responsible for that specific draft, after which the WEEL documentation is submitted to Toxicology and Industrial Health (TIH), a peer-reviewed medical journal that covers research in the fields of occupational health and toxicology, for publication. A thorough review of the galley proof by the scientific content quality coordinator at TERA, and proofreaders and editors at TIH is the penultimate step before eventual publication of the WEEL documentation.

The WEEL Committee

The OARS-WEEL Committee is composed of volunteer experts specializing in the scientific determination of occupational exposure levels. This committee actively seeks a balanced representation of professionals from toxicology and industrial hygiene, drawing upon a diverse range of experience from industry, government, academia, and consulting. Importantly, each member contributes to the Committee based on their individual expertise and not as an official representative of their respective employer, organization, or agency.